HELLO! I’m Roland Yan
Neuroscience researcher and graduate student at Mount Sinai.

  • 4+ Years Experience
  • 10+ Projects
  • 1 Publications

About Me

I’m an MSBS student at the Icahn School of Medicine at Mount Sinai, an EMT, and an aspiring MD/PhD candidate. I graduated from NYU Tandon in 2025, majoring in Biomolecular Engineering with a minor in Mathematics. At NYU Engineering, and later NYU Langone, I generated embedded-sensing synthetic skin and studied DYRK1A–APP interactions in Down syndrome mice. Afterwards, I interned at Columbia Engineering, studying geothermal heat reactors and passive tracking solar. Later at Pfizer Vaccine R&D, I developed CNN protein mutagenesis systems, viral sequence databasing, and experimental remote automation. Now, as a graduate student in the Castellano Lab, I investigate ApoE3/4 plasma proteomics in aging and design machine-learning morphology pipelines.

Core Skills

  • Mouse genetics & husbandry
  • Parabiosis & perfusion
  • Microfluidics
  • Brain slicing & tissue processing
  • In situ hybridization (Arc)
  • Molecular biology (PCR, cloning)
  • Protein engineering & NGS
  • Protein generative AI / LLMs
  • AlphaFold2 / structure prediction
  • PyRosetta / protein modeling
  • Python (scientific computing)
  • Docker & Git/GitHub

Other Skills

  • R (statistics)
  • Benchling
  • CAD & 3D printing
  • CNC milling & prototyping
  • Soft robotics & biosensors
  • Project management
  • Public speaking
  • Clinical teamwork (EMT / ALS-BLS)

Work Experience

Sep 2025 – Present

Mount Sinai | Castellano Laboratory

Graduate Student Researcher

Researching peripheral blood-borne factors in ApoE context mice and LGALS3 mechanisms using parabiosis, microfluidics, perfusions, and structural experiments.

  • Parabiosis + plasma injections + microfluidics + perfusion workflows to profile circulating peripheral Apoe4 factors that impact the brain.
  • Developed machine-learning based morphology pipelines for automated analysis of Microglia and OLs
Jan 2024 – Aug 2025

NYU Langone Health | William Laboratory (Neuropathology)

Student Researcher

Studied DYRK1A trisomy and its impact on synaptic plasticity in Down syndrome model mice, including cell-type specific manipulations and pharmacologic rescue.

  • Excitatory/inhibitory neuron targeting (Cre lines), pharmacological inhibition, and rescue experiments.
  • Mouse genetics, brain slicing, live imaging, Arc in situ hybridization, and molecular biology.
Mar 2025 – Present

SeniorCare EMS

Emergency Medical Technician (EMT)

911 BLS EMT at Saint Barnabas Hospital and ALS operator supporting paramedic-led emergencies across NYC hospital systems.

  • 911 standard BLS calls through Saint Barnabas Hospital NYC.
  • ALS emergencies with paramedics, operator and tech for complex ALS transports
Jun 2022 – Aug 2024

Pfizer Inc. | Summer Growth Experience (SGE)

ML / Vaccine Research Intern

Built protein generative-AI pipelines and supported protein engineering experiments for improved enzyme variants.

  • Protein generative AI using ProGen1, ProtGPT, and RITA; evaluation with AlphaFold2 and PyRosetta.
  • Engineered Phi29 polymerase variants; supported cell-free expression, NGS, purification, and cloning workflows.
Jan 2023 – Nov 2023

NYU Tandon | Rui Li Laboratory (UGSRP & VIP)

BioRobotics Researcher

Developed soft-robotic prosthetics and flexible biosensors for pressure/electro sensitivity in wearable systems.

  • Soft robotic pneumatic fingers and silicone-based prosthetic prototypes.
  • Flexible biosensors using laser-etched graphite sheets embedded in silicone; led UGSRP team work.
Jun 2022 – Oct 2023

NYU | Winawer Laboratory (Neurobiology)

Research Intern

Helped train ML models for retinotopic visual cortical mapping and generated dorsal/ventral visual cortex maps.

  • Docker-based pipelines for V1–V5 mapping from ultrahigh-field fMRI retinotopic datasets.
  • ML-assisted contouring and validation of retinotopic graphs across large cohorts.
Sep 2017 – May 2018

Columbia University | Carleton Laboratory (NSF REU)

Research Fellow

Designed, modeled, and tested novel passive ground heat exchanger systems (NSF-supported).

  • Numerical modeling + prototyping of bidirectional passive heat exchanger concepts.
  • Machining/testing of thermally-driven pump systems and phase-change materials integration.
2018

Columbia University | Carleton Laboratory (ENGI 3900)

Student Researcher

Project work spanning nanocrystal filtration, N95 mask reuse/disinfection systems, and passive solar tracking.

  • Nanocrystal tech (MnOx–CeO₂) for aldehyde filtration; passive solar tracker prototype.
  • N95 mask reuse/disinfection systems with 20k+ reads/downloads; collaboration for deployment impact.

Clinicals & Volunteering

Aug 2025 – Present

Mount Sinai | EHHOP Free Clinic

ACT Case Manager

Student-run primary care clinic serving uninsured patients; manage case logistics and connect patients to resources.

  • Coordinate appointments/logistics and follow-ups for individual patient cases.
  • Provide social resources (transportation, financial/legal support, food security).
Aug 2025 – Present

Mount Sinai Hospital Emergency Department

CARE ED Volunteer

Supportive ED volunteering focused on patient comfort and communication.

  • Provide materials/care packages and sit with patients in the ED.
  • Assist with non-clinical support to improve patient experience.
Jan 2024 – Present

NYU Langone Health | Neuropathology

Clinical Shadowing

Shadowed day-to-day neuropathology workflow including case discussion, smears/staining, and tumor board exposure.

  • Observed clinical operations and diagnostic reasoning in neuropathology.
  • Attended journal clubs, tumor board, and anatomical case studies.

Latest works

Protein Generative AI (Pfizer SGE)

Built protein generative-AI pipelines using ProGen1, ProtGPT, and RITA, with structure evaluation via AlphaFold2 and PyRosetta.

Protein Generative AI (Pfizer SGE)

DYRK1A Trisomy & Visual Cortical Plasticity

Down syndrome mouse-model research on synaptic plasticity and cell-type specific mechanisms, including Arc in situ hybridization and pharmacologic rescue.

DYRK1A Trisomy & Visual Cortical Plasticity

Youth-Associated Blood Factors & TIMP2 (Castellano Lab)

Studying circulating youth-associated factors and TIMP2/ECM microenvironmental effects using parabiosis, microfluidics, and perfusion workflows.

Details
Youth-Associated Blood Factors & TIMP2 (Castellano Lab)

Soft Robotic Prosthetics & Flexible Biosensors

Developed silicone pneumatic finger prosthetics and thin, flexible pressure/electro-sensitive biosensors for wearable bio-robotics applications.

Details
Soft Robotic Prosthetics & Flexible Biosensors

N95 Mask Reuse Disinfection Systems

Research on scalable disinfection systems for N95 reuse with real-world deployment goals; prior work reached 20k+ reads/downloads.

Details
N95 Mask Reuse Disinfection Systems

Retinotopic Visual Cortex Mapping (Winawer Lab)

ML-assisted cortical mapping and Docker-based pipelines generating dorsal/ventral visual cortex (V1–V5) maps from ultrahigh-field fMRI datasets.

Details
Retinotopic Visual Cortex Mapping (Winawer Lab)

NSF REU: Functionally Graded Materials Conference

Presented research at the Functionally Graded Materials Conference through an NSF REU program.

Details
NSF REU: Functionally Graded Materials Conference

ENG3900: Passive-Tracking Solar & Piezoelectric Energy

Developed passive tracking solar panel systems using thermal expansion systems and deep sea piezoelectric energy generators.

Details
ENG3900: Passive-Tracking Solar & Piezoelectric Energy